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December 1983

Pheochromocytoma Resistant to a-Adrenergic Blockade

Author Affiliations

From the Medical Service of the Veterans Administration Medical Center, East Orange, NJ, and the Department of Medicine of the University of Medicine and Dentistry—New Jersey Medical School, Newark.

Arch Intern Med. 1983;143(12):2321-2323. doi:10.1001/archinte.1983.00350120115025

• In a 54-year-old man with a norepinephrine-secreting pheochromocytoma, resistance developed to the α-adrenergic blocking agent, phenoxybenzamine hydrochloride. Dosages of 240 mg/day were ineffective. Intravenous phentolamine mesylate reduced his BP at first, but resistance developed to this also. Therapy with α-methylparatyrosine, an inhibitor of catecholamine biosynthesis, finally controlled his BP, and the tumor was removed.

(Arch Intern Med 1983;143:2321-2323)