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February 1984

Successful Combination Chemotherapy for Metastatic Parathyroid Carcinoma

Author Affiliations

From the Departments of Hematology and Medical Oncology (Drs Bukowski and Cunningham), Endocrinology (Dr Sheeler), and General Surgery (Dr Esselstyn), Cleveland Clinic Foundation.

Arch Intern Med. 1984;144(2):399-400. doi:10.1001/archinte.1984.00350140229032

• A 54-year-old patient with metastatic parathyroid carcinoma and severe hypercalcemia refractory to conventional treatment was treated with chemotherapy consisting of fluorouracil, 500 mg/sq m intravenously (IV) daily for four days (24-hour infusion), cyclophosphamide, 500 mg/sq m IV daily for four days, and dacarbazine (imidazole carboxamide), 200 mg/sq m IV daily for four days. Complete objective and partial biochemical responses were noted, with the response duration being 5.0+ months. The toxic reaction was moderate and predominantly gastrointestinal.

(Arch Intern Med 1984;144:399-400)

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