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February 1984

Thrombocytosis as a Feature of Iron-Deficiency Therapeutic Correction

Author Affiliations

Creteil, France

Arch Intern Med. 1984;144(2):414-415. doi:10.1001/archinte.1984.00350140248042

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To the Editor.  —Mild thrombocytosis is commonly seen in patients with iron deficiency anemia.1 Furthermore, platelets increase on iron therapy, sometimes reaching levels higher than the pretherapeutic level.2 In some rare cases, platelet counts higher than 1,000×103/cu mm were observed.3 However, this latter finding is peculiar to children receiving parenteral iron therapy. Conversely, we have been unable to discover any article of such a high thrombocytosis in the much more common situation of adult patients receiving oral iron therapy.

Report of a Case.  —A 23-year-old man was admitted to the Henri Mondor Hospital, Creteil, France, because of weakness. Clinical data were normal, except for splenomegaly (palpable 5 cm below the costal margin). Blood test results were as follows: hematocrit, 0.30%; hemoglobin, 5.1 g/dL; mean corpuscular volume (MCV), 66 pg; platelets, 245× 103/cu mm (on three occasions); serum iron, 5.5 μg/dL (normal, 9 to

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