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—We thank Dr Søgaard for his comments. His generalization that NAG excretion is correlated with GFR should not always be applied when one is comparing different types of disease. For example, our patients with obstructive nephropathy had higher serum creatinine values than our patients with membranous nephropathy (5.7±2.2 [mean±SD] v 2.1±1.9; P<.01) while they had lower values for NAG excretion (117±61 v 410±349; P<.01). Thus, we think that more exhaustive statistical analysis of our entire data in the suggested manner would not be fruitful.
Sherman RL, Drayer DE, Leyland-Jones BR, Reidenberg M. N-acetyl-ß-glucosaminidase and ß2-Microglobulin in Renal Disease-Reply. Arch Intern Med. 1984;144(2):421. doi:10.1001/archinte.1984.00350140255056
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