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March 1984

Spontaneous Factor XI Inhibitors: Seven Additional Cases and a Review of the Literature

Author Affiliations

From the Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Yale University School of Medicine (Drs Reece, Romero, and Hobbins), and the Department of Clinical Laboratories, Yale—New Haven Medical Center, New Haven, Conn (Mr Clyne).

Arch Intern Med. 1984;144(3):525-529. doi:10.1001/archinte.1984.00350150119031

• Circulating anticoagulants are endogenous blood components that inhibit the action of clotting factors. In some inhibitor conditions this inactivation in the function of the hemostatic system may lead to life-threatening hemorrhagic diathesis. Inhibitors directed against factor XI are generally associated with little or no impairment of the hemostatic system. We analyzed all reported cases of spontaneous factor XI inhibitor in the international literature, as well as cases identified at the Yale—New Haven (Conn) Hospital between 1970 and 1980, considering clinical spectrum, diagnosis, and therapy.

(Arch Intern Med 1984;144:525-529)

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