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July 1984

Acute Hepatic Injury Associated With Minocycline

Author Affiliations

From the Division of Gastroenterology (Drs Burette and Deltenre), the Departments of Medicine (Drs Burette, Finet, Prigogine, and Deltenre) and Pathology (Dr De Roy), the Brugmann Hospital, the Free University of Brussels.

Arch Intern Med. 1984;144(7):1491-1492. doi:10.1001/archinte.1984.00350190199034

• Minocycline hydrochloride hepatotoxic effect occurred in one patient. Unlike the usual histologic features of tetracycline-induced hepatic injury, fatty metamorphosis was predominantly macrovesicular. The patient recovered when drug therapy was withdrawn. Close observation of liver function variables is recommended in patients treated with high parenteral doses of minocycline, particularly in cases of pregnancy or renal disease.

(Arch Intern Med 1984;144:1491-1492)