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October 1984

Seminar presents research in struggle against cardiovascular problems

Arch Intern Med. 1984;144(10):1921-1925. doi:10.1001/archinte.1984.04400010025001

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Cardiovascular disease is expected to be the leading cause of death in the United States again this year. In this roundup, which began in last month's PRIMARY CARE MEDICINE, some approaches to the problem—as discussed at an American Heart Association seminar in St Petersburg Beach, Fla—are examined.

Lesions at the Genetic Level: Amidst talk of plasma apolipoprotein levels being a more accurate indicator for risk of coronary artery disease than high- and low-density lipoprotein levels, Jan L. Breslow, MD, posited that the ultimate indicator is genetic markers, which could be tested for at any

Investigators are well on their way toward identifying such markers. Breslow, who is professor of biochemical genetics and metabolism, Rockefeller University, New York City, says the genes have now been i solated for five of nine well-characterized apolipoproteins, the outer protein component of cholesterol-carrying lipoproteins. He and his colleagues are involved with four of these: two

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