• The renin-angiotensin system is a major determinant of arterial pressure and intravascular volume in human beings. Recent evidence, however, suggests that renin can be synthesized at local tissue sites and that these local renin-angiotensin systems subserve important physiologic functions. in addition, It appears that there exist Intracellular renin-angiotensin "systems" capable of generating angiotensin II intracellularly.
(Arch Intern Med 1984;144:2037-2041)