[ill]atients with acquired immune deficiency syndrome (AIDS) are susceptible to infection with a [ill]riety of opportunistic pathogens. Pneumocystis [ill]inii pneumonia is the major opportunistic infec[ill]n associated with the syndrome, while Candida[ill]icans and Cryptococcus neoformans are the most [ill]mmon fungi causing disease in AIDS.1 We first [ill]spected that AIDS predisposed to disseminated [ill]toplasmosis in a patient we examined in 1981.2 [ill]ce then, the association has been clearly established, with 15 cases reported in six US cities3-7 and in Trinidad.8 Only one of these occurred outside an endemic area.6 Of 19 patients with AIDS examined by either Bonner and co-workers3 in Birmingham, Ala, in this issue (four patients) or by Zeckel et al (unpublished observations) in Indianapolis (15 patients), ten patients (53%) had disseminated histoplasmosis, clearly demonstrating the prevalence of this opportunistic infection in patients with AIDS residing in endemic areas. Early localization of AIDS to New York City and San Francisco
Wheat LJ, Small CB. Disseminated Histoplasmosis in the Acquired Immune Deficiency Syndrome. Arch Intern Med. 1984;144(11):2147–2149. doi:10.1001/archinte.1984.04400020049006
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