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December 1984

Steroid-Dependent Nephrotic Syndrome in Lupus Nephritis: Response to Chlorambucil

Author Affiliations

From the Departments of Medicine (Drs Abuelo and Garella) and Pathology (Dr Esparza), Rhode Island Hospital, and the Division of Biological and Medical Sciences, Brown University (Drs Abuelo, Esparza, and Garella), Providence, RI.

Arch Intern Med. 1984;144(12):2411-2412. doi:10.1001/archinte.1984.00350220141030

• Nephrotic syndrome associated with mesangial lupus nephritis developed in a young woman. The heavy proteinuria exhibited a striking steroid-dependent course during a three-year period of time, with ten relapses occurring whenever attempts were made to withdraw prednisone therapy. A prolonged remission was induced by the administration of chlorambucil.

(Arch Intern Med 1984;144:2411-2412)

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