• The drug interaction between warfarin and erythromycin is not well known. We report a case in which erythromycin was observed to markedly potentiate warfarin anticoagulation, resulting in hemorrhage in a patient treated for Legionella pneumonia. The morbidity of this drug interaction is enhanced in elderly patients who have infection accompanied by anorexia and/or fever and who are receiving intravenous erythromycin. The well-documented, temporal relationship established erythromycin as the interacting drug.
(Arch Intern Med 1984:144:2413-2414)
Ronald I. Sato, David R. Gray, Stephen E. Brown. Warfarin Interaction With Erythromycin. Arch Intern Med. 1984;144(12):2413–2414. doi:10.1001/archinte.1984.00350220145031