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December 1984

Amiodarone Therapy and Hyperthyroidism in Europe

Arch Intern Med. 1984;144(12):2429. doi:10.1001/archinte.1984.00350220165038

To the Editor.  —I was very much interested in the article by Amico et al in the March issue of the Archives.1 It reported a well-conducted prospective study, whereas most articles published so far have reported retrospective or sporadic cases, including, I admit, my colleagues' and my own observations on the subject. It nevertheless confirmed what has been known for years in Europe.The most interesting feature of this study is that no cases of hyperthyroidism were detected as opposed to five cases of hypothyroidism. In two of the five, antithyroid antibodies were found, confirming the hypothesis we presented long ago that an already-diseased gland will be more likely to have complications if amiodarone is prescribed and that a pretreatment search for antibodies is an excellent and inexpensive way to detect patients who are at risk. In Europe, hyperthyroidism is more common than hypothyroidism as a complication of amiodarone

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