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January 1985

Renal Function Following Infusion of Radiologic Contrast Material: A Prospective Controlled Study

Author Affiliations

From the Division of Nephrology, Royal Victoria Hospital, Montreal (Drs Parfrey, Hutchinson, Baran, and Seely), and the Department of Radiology, Montreal Neurological Institute, McGill University, Montreal (Drs Cramer, Melanson, and Ethier). Dr Parfrey is now at Memorial University, St John's, Newfoundland.

Arch Intern Med. 1985;145(1):87-89. doi:10.1001/archinte.1985.00360010115018

• In a prospective, controlled study undertaken to assess renal function following infusion of radiologic contrast material, serum creatinine level was determined before scan and for three days after scan in 193 patients undergoing computed tomographic (CT) brain scan with contrast enhancement (contrast medium volume, 60 to 350 mL) and in 233 controls undergoing CT scan without infusion. Renal failure developed in four patients who had infusion of contrast material and in three patients who had no infusion (≥50% increase in serum creatinine level and above normal). In the high-risk group (serum creatinine level ≥1.5 mg/dL or diabetes mellitus), renal failure developed in none of the 19 patients infused and in two of 46 in the noninfused group. It was concluded that previous uncontrolled studies may have overestimated the risk of renal failure induced by contrast material.

(Arch Intern Med 1985;145:87-89)

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