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January 1985

Hypercalcemia in the Neuroleptic Malignant Syndrome

Author Affiliations

From the Medical and Research Services, Veterans Administration Wadsworth Medical Center; and the Department of Medicine, UCLA School of Medicine, Los Angeles. Dr Carlson is now with the Harry S Truman Memorial Veterans Hospital, Columbia, Mo.

Arch Intern Med. 1985;145(1):143-144. doi:10.1001/archinte.1985.00360010181032

• The neuroleptic malignant syndrome (NMS) developed in a 32-year-old man following fluphenazine enanthate administration. Hypercalcemia was initially present, perhaps reflecting release of calcium from skeletal muscle stores. The elevated serum calcium levels support the existence of a peripheral muscle abnormality in the pathogenesis of the NMS and provides another point of similarity between NMS and malignant hyperthermia.

(Arch Intern Med 1985;145:143-144)