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January 1985

Acute Tubular Necrosis After Inhalation Exposure to Methylene Chloride: Report of a Case

Author Affiliations

From the Departments of Medicine (Drs Miller and Pateras) and Pathology (Drs Friederici and Engel), Evanston (Ill) Hospital; and the Department of Clinical Medicine, Northwestern University Medical School, Chicago (Dr Pateras).

Arch Intern Med. 1985;145(1):145-146. doi:10.1001/archinte.1985.00360010187033

• Nephrotoxic reaction occurred after inhalation exposure to methylene chloride. This exposure is associated with acute renal failure, myoglobinuria, hypocomplementemia, and liver enzyme elevations. Pathologic specimens, both light and electron microscopic, demonstrate renal tubular damage. We conclude that methylene chloride may have potential as both a hepatotoxic and nephrotoxic agent when inhaled at high concentrations over an extended period of time.

(Arch Intern Med 1985;145:145-146)