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April 1985

Moderate Weight Loss and Sulfonylurea Treatment of Non—insulin-dependent Diabetes Mellitus: Combined Effects

Author Affiliations

From the Department of Medicine, Stanford (Calif) University School of Medicine (Drs Liu, Lardinois, Hollenbeck, and Reaven and Mss Coulston and Moore), and the Geriatric, Education and Clinical Center, Veterans Administration Medical Center, Palo Alto, Calif (Dr Reaven).

Arch Intern Med. 1985;145(4):665-669. doi:10.1001/archinte.1985.00360040087020

• Hypocaloric liquid formula diets were given for one month to 20 moderately obese patients with non—insulin-dependent diabetes mellitus divided into two equal groups; group 1 was treated with weight loss alone; group 2 received glipizide in addition to the hypocaloric diet. Mean weight loss was similar in the two groups (6.5 ±0.6 v 6.4 ±0.5 kg) and was associated with a statistically significant fall in mean fasting plasma glucose values from 293±15 to 232±24 mg/dL (group 1) and from 281±15 to 152 ±7 mg/dL (group 2). This was associated with 13% (group 1) and 36% (group 2) decrements in total postprandial glucose response. Neither fasting nor postprandial insulin levels changed significantly with weight loss, but estimates of insulin-stimulated glucose disposal demonstrated a 15% (group 1) and 42% (group 2) improvement. Finally, fasting plasma cholesterol and triglyceride concentrations fell significantly in both groups.

(Arch Intern Med 1985;145:665-669)