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May 1985

Seronegative Spondyloarthropathies in Lone Aortic Insufficiency

Author Affiliations

From the Rheumatology Division (Drs Qaiyumi and Toone) and Cardiology Division (Dr Ul Hassan), Medical Service, McGuire Veterans Administration Medical Center; and the Medical College of Virginia (Drs Qaiyumi and Hassan), Richmond.

Arch Intern Med. 1985;145(5):822-824. doi:10.1001/archinte.1985.00360050066010

• We evaluated 100 consecutive cases of lone aortic insufficiency (Al) for the prevalence of seronegative spondyloarthropathies. Four patients were found to have ankylosing spondylitis and three had Reiter's syndrome. Six of these seven patients had cardiac conduction abnormalities, four of which required permanent pacemaker insertion. All seven were found to have the HLA-B27 antigen, whereas of 89 patients tested with no evidence of spondylitis only five had the antigen. The seronegative spondyloarthropathies apparently are associated frequently with lone Al. The morbidity and mortality of these patients increases when they develop cardiovascular abnormalities including Al and heart block, which may dominate the clinical picture. The HLA-B27 antigen is not specifically associated with lone Al in the absence of spondylitis.

(Arch Intern Med 1985;145:822-824)