• Recently, ketoconazole, an imidazole derivative with antifungal properties, has been shown to inhibit adrenal corticosteroid and androgen production. We treated a patient with small-cell lung cancer and Cushing's syndrome secondary to ectopic secretion of adrenocorticotropic hormone in whom it was necessary to discontinue chemotherapy. The patient was treated with ketoconazole, with a resultant reduction in urinary free cortisol and ketosteroid excretion and improvement in electrolyte balance. Ketoconazole may be a useful adjunct in the treatment of small-cell lung cancer or other malignancies associated with excessive corticosteroid production or as a hormonal therapy in breast or prostatic cancer.
(Arch Intern Med 1985;145:863-864)
Shepherd FA, Hoffert B, Evans WK, Emery G, Trachtenberg J. Ketoconazole: Use in the Treatment of Ectopic Adrenocorticotropic Hormone Production and Cushing's Syndrome in Small-Cell Lung Cancer. Arch Intern Med. 1985;145(5):863–864. doi:https://doi.org/10.1001/archinte.1985.00360050119020
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