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May 1985

Thrombocytopenia of Sepsis: The Role of Circulating IgG-Containing Immune Complexes

Author Affiliations

From the Mt Home Veterans Administration Medical Center, and the Department of Internal Medicine, East Tennessee State University, Quillen-Dishner College of Medicine, Johnson City, Tenn.

Arch Intern Med. 1985;145(5):891-894. doi:10.1001/archinte.1985.00360050155026

• Platelet-associated IgG (PAIgG), circulating IgG-containing immune complexes (ICs), plasma β-thromboglobulin (β-TG), and platelet factor 4 (PF-4) levels were assayed in 33 consecutive patients with culture-proved bacteremia. Thrombocytopenia occurred in 18%, and no correlation was seen between platelet count and PAIgG, β-TG, or PF-4. In contrast, when patients were assigned to groups on the basis of rising or stable counts vs falling counts, a significant increase in the frequency of elevated PAIgG was seen in those with falling platelet counts. Elevated ICs did not correlate with PAIgG, platelet count, β-TG, or PF-4. The results of this study of patients with uncomplicated bacteremia, although clearly demonstrating intravascular platelet activation and suggesting a pathologic role for elevated PAIgG, do not support the hypothesis that platelet-bound serum ICs are responsible for either phenomenon.

(Arch Intern Med 1985;145:891-894)

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