• "Drug holiday," the withdrawal of levodopa for a variable period of time, is a controversial method of treating patients with Parkinson's disease who have levodopa-related complications. Only four studies have been published in which patients were observed for one year or longer. Although it is extremely beneficial for some patients, this treatment provides a sustained one-year benefit for only a minority of patients.
(Arch Intern Med 1985;145:913-915)
Friedman JH. 'Drug Holidays' in the Treatment of Parkinson's Disease: A Brief Review. Arch Intern Med. 1985;145(5):913–915. doi:10.1001/archinte.1985.00360050183031
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