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May 1985

Small-Cell Lymphoma and Sjögren's Syndrome: Lymphoplasmacytic Subvariant of Small-Cell Lymphoma With IgA/? Immunoglobulin Surface Markers

Author Affiliations

From the Departments of Medicine (Drs Askari and Rassiga) and Pathology (Drs Hogrefe and Laipply), Case Western Reserve University School of Medicine; and the Divisions of Rheumatology (Drs Laqui and Askari) and Hematology (Dr Rassiga), St Luke's Hospital and Veterans Administration (VA) Medical Center, Cleveland. Dr Laqui was a fellow of the Division of Rheumatology, St Luke's Hospital, Cleveland.

Arch Intern Med. 1985;145(5):935-937. doi:10.1001/archinte.1985.00360050205039

• To our knowledge, the association of the plasmacytoid variety of small-cell lymphoma with primary Sjögren's syndrome has not been reported. We describe a patient with SS who developed plasmacytoid small-cell lymphoma. As opposed to the commonly detected IgM, the lymphocyte surface immunoglobulins contained monoclonal IgA/κ light chains. In addition to the unique immunopathologic features, the impressive response to chemotherapy and the importance of surface immunoglobulin markers in the diagnosis of malignancy in Sjögren's syndrome are discussed.

(Arch Intern Med 1985;145:935-937)

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