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May 1985

Intravenous Immune Globulin Therapy: Treatment of a Patient With Severe Immunodeficiency, Chronic Malabsorption, and Fulminant Septicemia

Author Affiliations

From the Division of Immunology-Rheumatology, Departments of Internal Medicine (Drs Gonzalez, Ichikawa, and Daniels), Pharmacy (Dr Guernsey), and Pharmacology (Dr Ingrim), University of Texas Medical Branch Hospitals, Galveston.

Arch Intern Med. 1985;145(5):945-946. doi:10.1001/archinte.1985.00360050215042

• Biweekly 200 mg/kg infusions of immune globulin (Gamimune) were given to a 46-year-old woman with severe common variable immunodeficiency, bronchiectasis, and chronic diarrhea with malabsorption. Failure to achieve therapeutically effective serum IgG concentrations in the face of fulminant sepsis was accompanied by a shortened serum IgG half-life of 10.6 days. Currently recommended doses of 200 mg/kg may prove inadequate in very ill patients with sepsis and malabsorption.

(Arch Intern Med 1985;145:945-946)