• Biweekly 200 mg/kg infusions of immune globulin (Gamimune) were given to a 46-year-old woman with severe common variable immunodeficiency, bronchiectasis, and chronic diarrhea with malabsorption. Failure to achieve therapeutically effective serum IgG concentrations in the face of fulminant sepsis was accompanied by a shortened serum IgG half-life of 10.6 days. Currently recommended doses of 200 mg/kg may prove inadequate in very ill patients with sepsis and malabsorption.
(Arch Intern Med 1985;145:945-946)
Gonzalez EB, Guernsey BG, Ingrim NB, Ichikawa Y, Daniels JC. Intravenous Immune Globulin Therapy: Treatment of a Patient With Severe Immunodeficiency, Chronic Malabsorption, and Fulminant Septicemia. Arch Intern Med. 1985;145(5):945–946. doi:10.1001/archinte.1985.00360050215042
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