[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
May 1985

Intravenous Immune Globulin Therapy: Treatment of a Patient With Severe Immunodeficiency, Chronic Malabsorption, and Fulminant Septicemia

Author Affiliations

From the Division of Immunology-Rheumatology, Departments of Internal Medicine (Drs Gonzalez, Ichikawa, and Daniels), Pharmacy (Dr Guernsey), and Pharmacology (Dr Ingrim), University of Texas Medical Branch Hospitals, Galveston.

Arch Intern Med. 1985;145(5):945-946. doi:10.1001/archinte.1985.00360050215042

• Biweekly 200 mg/kg infusions of immune globulin (Gamimune) were given to a 46-year-old woman with severe common variable immunodeficiency, bronchiectasis, and chronic diarrhea with malabsorption. Failure to achieve therapeutically effective serum IgG concentrations in the face of fulminant sepsis was accompanied by a shortened serum IgG half-life of 10.6 days. Currently recommended doses of 200 mg/kg may prove inadequate in very ill patients with sepsis and malabsorption.

(Arch Intern Med 1985;145:945-946)