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July 1985

Branched-Chain Amino Acids in Sepsis and Hepatic Failure

Author Affiliations

From the Section of Critical Care Medicine and the Department of Medicine, Cook County Hospital, Chicago.

Arch Intern Med. 1985;145(7):1284-1288. doi:10.1001/archinte.1985.00360070164028

• The pathophysiologic mechanisms for the metabolism of hepatic failure and severe sepsis are complex, and in many ways similar. The similarities concern abnormalities in peripheral and hepatic protein metabolism. The ability of enteral and parenteral solutions containing increased amounts of branched-chain amino acids to ameliorate many of the derangements observed in these disease states relates to this shared pathophysiology.

(Arch Intern Med 1985;145:1284-1288)