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Boelaert et al are right in pointing out that C6, C7, and C8 are not the only hereditary complement deficiencies associated with recurrent neisserial sepsis, as illustrated by their family study and their list of previously published case studies.
We have emphasized in our report that C6, C7, and C8 deficiency are the most commonly encountered complement deficiencies associated with neisserial sepsis, but they are obviously not the only ones.
Hershko C, Zimran A, Kuperman O, Shemesh O. C5 Deficiency in a White Family-Reply. Arch Intern Med. 1985;145(7):1334. doi:10.1001/archinte.1985.00360070216047
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