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August 1985

Multiple Myeloma in Three Siblings

Author Affiliations

From the Department of Medicine (Division of Hematology/Oncology), Long Island Jewish Medical Center, New Hyde Park, NY. Dr Horwitz is now with the Department of Hematology, University of Texas M. D. Anderson Hospital, Houston.

Arch Intern Med. 1985;145(8):1449-1450. doi:10.1001/archinte.1985.00360080123018

• All three siblings of a family developed multiple myeloma. Two siblings had a history of monoclonal gammopathy; in one of these two siblings and in the third sibling, the disease progressed rapidly. A review of the literature shows that of 38 previously reported pairs of siblings with plasma cell disorders, eight families had a third affected sibling and four another affected relative. This clinical clustering suggests that some cases of multiple myeloma may have a hereditary basis and that other family members may be at risk for developing the disease.

(Arch Intern Med 1985;145:1449-1450)