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August 1985

Hyperthyroidism After Primary Hypothyroidism: Follow-up With Serial Thyroid Biopsies

Author Affiliations

From the Department of Internal Medicine, Toyama (Japan) Prefectural Central Hospital (Drs Wakakuri and Kubo), and the Department of Pathology, Faculty of Medicine, Toyama (Japan) Medical and Pharmaceutical University (Dr Kitagawa).

Arch Intern Med. 1985;145(8):1527-1528. doi:10.1001/archinte.1985.00360080209034

• Hyperthyroidism occurred following primary hypothyroidism in a 46-year-old man with serologically and histologically proved chronic lymphocytic thyroiditis. Repeated thyroid biopsy specimens revealed that histologic features compatible with chronic lymphocytic thyroiditis seen at the initial hypothyroid state subsequently underwent a remarkable resolution, with titers of circulating antithyroid antibodies being reduced in correspondence with the histologic improvement. This case shows that primary hypothyroidism in adults can spontaneously evolve into a hyperthyroid state, as has been suggested previously, and that the histologic abnormalities in chronic lymphocytic thyroiditis may not necessarily be irreversible.

(Arch Intern Med 1985;145:1527-1528)

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