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September 1985

Time Course of Serum Cardiac Enzymes After Intracoronary Thrombolytic Therapy: Creatine Kinase, Creatine Kinase MB Isozyme, Lactate Dehydrogenase, and Serum Glutamic-Oxaloacetic Transaminase

Author Affiliations

From the Charles A. Dana Research Institute and the Harvard-Thorndike Laboratory, Department of Medicine, Beth Israel Hospital and Harvard Medical School, Boston.

Arch Intern Med. 1985;145(9):1596-1600. doi:10.1001/archinte.1985.00360090060010

• We analyzed the time course of serum creatine kinase (CK), the CK MB isozyme, lactate dehydrogenase (LDH), and serum glutamic-oxaloacetic transaminase (SGOT) activity and calculated rates of increase and decline for CK in 24 consecutive patients with acute myocardial infarction (AMI) who received intracoronary thrombolytic therapy. In 19 patients with successfully reperfused infarcts, peak CK activity occurred at 14.1±1.1 hours after onset of symptoms, the maximal rate of CK rise was 595 ±102 IU/L/hr, and the fractional disappearance rate (Kd) was (86 ±6) × 10 -5 min. The peak CK MB activity occurred at 12.9 ±0.8 hours and the MB Kd was (223 ± 39) × 10 -5/min. In five patients in the nonreperfused group the peak CK (24.9±4.5 hours) and CK MB (22.7±3.3 hours) activity occurred later, the maximal rate of CK rise (281 ±37 IU/L/hr) was less, and the CK Kd [(68 ±5) × 10 -5/min] and

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