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September 1985

Rapidly Progressive Glomerulonephritis Accompanying Legionnaires' Disease

Author Affiliations

From the Medizinische Poliklinik and Medizinische Abteilung, Anna-Seiler-Haus, Inselspital, University of Berne (Switzerland).

Arch Intern Med. 1985;145(9):1711-1713. doi:10.1001/archinte.1985.00360090187028

• A rapidly progressive, crescentic glomerulonephritis with acute oliguric renal failure occurred simultaneously with legionnaires' disease (LD) in a 52-year-old man. The diagnosis of LD was based on a sixfold rise in indirect fluorescent antibody titer against Legionella pneumophila serogroup 4. Treatment with erythromycin lactobionate resulted in a clinical resolution of pulmonary manifestations. The impairment of kidney function, however, was progressive and within two weeks led to end-stage renal failure requiring regular hemodialysis. This observation suggests that LD may trigger severe acute glomerulonephritis.

(Arch Intern Med 1985;145:1711-1713)