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October 1985

The Frequency of Malignant Neoplasms in Patients With Polymyositis-Dermatomyositis: A Controlled Study

Author Affiliations

From the Department of Medicine, Women's College Hospital, University of Toronto (Dr Pritchard); University of Toronto Rheumatic Disease Unit (Drs Tenenbaum, Lee, and Gordon); and the Ontario Cancer Institute, Toronto (Dr Boyd and Ms Germanson). Messrs Manchul and Jin are medical students at the University of Toronto; Dr Pritchard is a Clinical Trials Scholar of the National Cancer Institute of Canada.

Arch Intern Med. 1985;145(10):1835-1839. doi:10.1001/archinte.1985.00360100097016

• Seventy-one patients with polymyositis-dermatomyositis (PM/DM) admitted to the Wellesley Hospital Rheumatic Disease Unit (RDU) in Toronto between 1965 and 1980 were followed up to 1981. The frequencies of malignant neoplasms occurring prior to or concurrent with initial RDU admission were compared, using case-control methods, with age- and sex-matched control groups with a diagnosis of any non— PM/DM rheumatic disease (rheumatic disease controls) or osteoarthritis, fibrositis, or fracture (noninflammatory musculoskeletal controls). In a cohort analysis, the incidence of malignant neoplasm subsequent to initial RDU admission in patients with PM/DM was compared with the expected incidence in the Canadian population. Fifteen of 71 patients with PM/DM had an antecedent or concurrent cancer compared with four of 71 rheumatic disease controls and one of 71 noninflammatory musculoskeletal controls. Cohort analysis showed no increase in the number of subsequent malignant neoplasms in patients with PM/DM compared with the age- and sex-matched Canadian population.

(Arch Intern Med 1985;145:1835-1839)

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