• Traditionally described as a triad consisting of recurrent aphthous stomatitis, genital ulcerations, and uveitis, Behçet's syndrome is now recognized as a multisystem disease with protean manifestations. We studied a patient with chronic recurrent migratory superficial thrombophlebitis and marked cutaneous hyperreactivity (pathergy) who developed leukocytoclastic vasculitis with recalcitrant leg ulcerations nine years after the onset of his illness. Although he was treated with topical and systemic antibiotics for presumed bacterial superinfection, cutaneous ulcerations continued to develop and enlarge; only after prednisone therapy was begun was there a dramatic response with complete resolution. Despite high-dose prednisone therapy, the pathergy test remained markedly positive; however, no new skin ulcerations appeared.
(Arch Intern Med 1985;145:1913-1915)
Plotkin GR, Patel BR, Shah VN. Behçet's Syndrome Complicated by Cutaneous Leukocytoclastic Vasculitis: Response to Prednisone and Chlorambucil. Arch Intern Med. 1985;145(10):1913–1915. doi:10.1001/archinte.1985.00360100187032
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: