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November 1985

Sarcoidosis and Reactive Pulmonary Hypertension

Author Affiliations

From the Cardiology Division, Departments of Pediatrics (Dr Barst) and Medicine (Dr Ratner), Columbia University College of Physicians and Surgeons, New York. Dr Barst is now with the Department of Pediatrics, New York Medical College, Valhalla.

Arch Intern Med. 1985;145(11):2112-2114. doi:10.1001/archinte.1985.00360110188037

• Despite diffuse disease of the lungs (often with widespread inflammation or obliteration of blood vessels) in sarcoidosis, pulmonary hypertension is uncommon, occurring in 1% to 4% of cases. We report a case of sarcoidosis and severe pulmonary hypertension that, in striking contrast to other reports, occurred in the absence of obliterative pulmonary vascular disease. We therefore examined the possibility of whether an abnormality in pulmonary vascular tone might be a cause of the pulmonary hypertension. In pharmacologic studies, we demonstrated pulmonary vasodilatation and, in response to increased pulmonary blood flow, the elaboration of the pulmonary vasoconstricting eicosanoid, thromboxane.

(Arch Intern Med 1985;145:2112-2114)

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