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November 1985

Failure of a-Methyltyrosine to Prevent Hypertensive Crisis in Pheochromocytoma

Author Affiliations

From the Departments of Internal Medicine (Drs Ram and Meese) and Oral Surgery (Dr Hill), University of Texas Health Science Center at Dallas.

Arch Intern Med. 1985;145(11):2114-2115. doi:10.1001/archinte.1985.00360110190038

• Sudden onset of a hypertensive crisis occurred shortly after induction of anesthesia in a patient with malignant pheochromocytoma, despite preoperative medical preparation with α-methyltyrosine (α-methyl-p-tyrosine) and propranolol hydrochloride. Other investigators have advocated α-methyltyrosine as the medical therapy of choice in the preoperative preparation of patients with pheochromocytoma. This case emphasizes the caution that should be exercised when using α-methyltyrosine preoperatively, without concurrent α-adrenergic blocking agents, to prevent intraoperative hypertensive crisis.

(Arch Intern Med 1985;145:2114-2115)