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December 1985

Recurrent Respiratory Disease, Azoospermia, and Nasal Polyposis: A Syndrome That Mimics Cystic Fibrosis and Immotile Cilia Syndrome

Author Affiliations

From the Division of Clinical Immunology and Allergy, Department of Medicine (Drs Schanker and Saxon), and the Division of Urology, Department of Surgery (Dr Rajfer), UCLA School of Medicine, Los Angeles.

Arch Intern Med. 1985;145(12):2201-2203. doi:10.1001/archinte.1985.00360120073012

• Three adult men with chronic sinopulmonary disease, nasal polyposis, and azoospermia were studied. All had normal sweat chloride values and pancreatic function. The azoospermia was due to a block in the epididymis that was distinguishable from the defect in the vas deferens seen in cystic fibrosis. Cilia structure was normal in sperm tails from testicular biopsy specimens and in cilia from tracheal biopsy specimens. These cases represent a clinical entity distinct from cystic fibrosis and known immotile cilia disorders.

(Arch Intern Med 1985;145:2201-2203)