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December 1985

Reserpine in Propranolol-Resistant Thyroid Storm

Author Affiliations

From the American University Medical Center, Beirut, Lebanon (Drs Anaissie and Tohmé). Dr Tohmé is now with Columbia University, New York, and Helen Hayes Hospital, West Haverstraw, NY.

Arch Intern Med. 1985;145(12):2248-2249. doi:10.1001/archinte.1985.00360120120020

• β-Adrenergic blockers are considered the drugs of choice in the management of the hyperadrenergic state in hyperthyroidism. However, we observed a patient in thyroid storm and coma who failed to respond to large doses of oral and intravenous propranolol hydrochloride but who responded promptly to intramuscular reserpine. Reserpine may have been lifesaving and should be considered in propranololresistant hyperthyroidism and in hyperthyroid patients in whom propranolol is contraindicated.

(Arch Intern Med 1985;145:2248-2249)

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