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March 1986

Immune Thrombocytopenia and Response to Splenectomy in Chronic Liver Disease

Author Affiliations

From the Divisions of General Internal Medicine and Health Services Research (Dr Skootsky) and Hematology/Oncology (Dr Rosove), Department of Medicine, and the Clinical Laboratories (Ms Langley), School of Medicine, UCLA School for the Health Sciences.

Arch Intern Med. 1986;146(3):555-557. doi:10.1001/archinte.1986.00360150185023

• Six patients had chronic liver diseases of diverse origin, persistent unexplained thrombocytopenia, and no palpable splenic enlargement. Platelet-associated IgG levels were increased in all cases. Two patients underwent splenectomy; the spleens weighed 375 and 230 g. Each patient had prompt, complete, and sustained platelet count normalization. Two other patients treated briefly with prednisone had no response. These observations indicate that a minimally enlarged spleen may be responsible for thrombocytopenia in chronic liver disease and suggest that immune mechanisms may contribute to thrombocytopenia in this setting.

(Arch Intern Med 1986;146:555-557)

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