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April 1986

Functional Dyspepsia and Chronic Idiopathic Gastric Stasis: Role of Endogenous Opiates

Author Affiliations

From the Gastrointestinal Unit, Departments of Medicine I (Drs Narducci, Bassotti, Gaburri, Farroni, and Morelli) and Nuclear Medicine (Drs Granata and Palumbo), University of Perugia (Italy).

Arch Intern Med. 1986;146(4):716-720. doi:10.1001/archinte.1986.00360160140019

• Chronic idiopathic gastric stasis can be responsible for unexplained dyspepsia. Because exogenous opiates inhibit gastric emptying and endogenouslike substances are present in the gastrointestinal tract, we tested the hypothesis that increased endogenous opiate activity may be responsible for chronic idiopathic gastric stasis. Eighteen patients with chronic idiopathic gastric stasis and ten healthy volunteers were studied by gastrointestinal manometry. Scintigraphic technique also was used, during which either intravenous saline or naloxone hydrochloride were infused. Manometry showed gastric hypomotility in ten patients and duodenal hyperdyskinesia in the remaining eight patients. Naloxone did not alter gastric emptying in healthy subjects or corrected gastric stasis in patients with gastric hypomotility, while it normalized gastric emptying in patients with duodenal dyskinesia. It seems that either gastroparesis or duodenal dyskinesia can promote gastric stasis and chronic dyspepsia, and endogenous opiates participate in the pathogenesis of gastric stasis in patients with duodenal dyskinesia.

(Arch Intern Med 1986;146:716-720)

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