• A 27-year-old patient manifested severe hemolytic anemia during a preleukemia phase. Low levels of adenosine triphosphate and decreased activity of pyruvate kinase were found. Acute myeloblastic leukemia developed in this patient 20 months later. The case suggests that acquired enzyme deficiency may play a role in the development of anemia in the preleukemic state.
(Arch Intern Med 1986;146:785-786)
Kornberg A, Goldfarb A. Preleukemia Manifested by Hemolytic Anemia With Pyruvate-Kinase Deficiency. Arch Intern Med. 1986;146(4):785–786. doi:10.1001/archinte.1986.00360160237030
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.