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April 1986

Successful High-Dose Intravenous Cytarabine Treatment of Parenchymal Brain Involvement From Malignant Lymphoma

Author Affiliations

From the Section of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee.

Arch Intern Med. 1986;146(4):791-792. doi:10.1001/archinte.1986.00360160243032

• A patient with systemic recurrence of large-cell malignant lymphoma developed radiologic evidence of parenchymal brain metastasis. Treatment with systemic high-dose cytarabine resulted in complete regression of peripheral adenopathy and complete radiologic response in the central nervous system, with normalization of the brain computed tomographic scan. This case further demonstrates the ability of high-dose cytarabine to penetrate the blood-brain barrier and achieve therapeutic drug concentrations in the central nervous system, an area that might otherwise remain a pharmacologic sanctuary for tumor cells.

(Arch Intern Med 1986;146:791-792)

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