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Article
May 1986

Low- vs High-Dose Aspirin: Effects on Platelet Function in Hyperlipoproteinemic and Normal Subjects

Author Affiliations

From the Department of Pathology (Dr Zucker and Mss Trowbridge and Woodroof) and the Lipid and Arteriosclerosis Prevention Clinic, Division of Clinical Pharmacology, Department of Medicine (Drs Chernoff and Dujovne and Mr Reynoso), University of Kansas School of Medicine, Kansas City.

Arch Intern Med. 1986;146(5):921-925. doi:10.1001/archinte.1986.00360170143021
Abstract

• Low-dose aspirin may be inadequate for inhibition of platelet function in hyperlipoproteinemics due to increased platelet reactivity. Platelet function was studied in 18 type II hyperlipoproteinemic and 12 normal subjects after at least ten days of treatment with placebo and with low-dose (0.45 mg/kg/day) and high-dose (900 mg/day) aspirin. In the normal and hyperlipoproteinemic subjects, low-dose aspirin produced near maximal (90%) inhibition of platelet thromboxane generation, significant prolongation of the bleeding time, and significant inhibition of platelet aggregation, similar in degree to the inhibition produced by high-dose aspirin. There was no significant difference between hyperlipoproteinemic and normal subjects in any of the platelet function measures before and after aspirin treatment. Thus, a daily 0.45-mg/kg aspirin dose (20 to 45 mg) effectively inhibited platelet function in type II hyperlipoproteinemics, who do not appear to have an increased dose requirement for aspirin.

(Arch Intern Med 1986;146:921-925)

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