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May 1986

Canada-Cronkhite Syndrome Associated With Systemic Lupus Erythematosus

Author Affiliations

From the Departments of Internal Medicine (Drs Kubo, Hirose, and Aoki) and Dermatology (Dr Kaji), Toyama (Japan) Prefectural Central Hospital, and the Department of Pathology, Faculty of Medicine, Toyama Medical and Pharmaceutical University (Dr Kitagawa).

Arch Intern Med. 1986;146(5):995-996. doi:10.1001/archinte.1986.00360170249031

• A 43-year-old woman with a history of systemic lupus erythematosus manifested severe diarrhea, generalized gastrointestinal polyposis, pigmentation, and onychodystrophy, which were typical of Canada-Cronkhite syndrome. The exacerbation of systemic lupus erythematosus, presenting with hemolytic anemia and subsequently with profound proteinuria, was seen during the course of this syndrome. The patient achieved complete symptomatic remissions of both entities for more than four years following prednisolone therapy; the resolution of the gastrointestinal polyps was confirmed histologically. This case showed that this syndrome could be completely reversible in its course and that it might have an exogenous cause, as previously suggested.

(Arch Intern Med 1986;146:995-996)

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