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June 1986

Liver Sinusoidal Dilatation in Familial Mediterranean Fever

Author Affiliations

Barcelona, Spain

Arch Intern Med. 1986;146(6):1243. doi:10.1001/archinte.1986.00360180263062

To the Editor.  —Familial Mediterranean fever (FMF) is an uncommon disease characterized by idiopathic, recurring, and self-limited attacks of febrile serosal inflammation involving the peritoneum, synovium, or pleura. Nonamyloid hepatic involvement in FMF has been described rarely as hepatitis1 or fatty degeneration.2 We report the case of a patient with FMF whose liver biopsy specimens demonstrated sinusoidal dilatation (SD). Since she had never taken oral contraceptives nor had hepatic outflow obstruction, we assumed that SD is related to FMF.To our knowledge, SD has not been described previously in association with FMF.

Report of a Case.  —A 27-year-old woman was admitted to the hospital because of fever of unknown origin. She was well until four years earlier when she began to experience febrile attacks consisting of a rapidly rising temperature to a peak of 38 °C to 39 °C lasting three to four days unassociated with serosal symptoms,

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