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August 1986

Meningococcemia and Acquired Complement Deficiency: Association in Patients With Hepatic Failure

Author Affiliations

From the Denver Veterans Administration Medical Center (Dr Ellison); the University of Colorado School of Medicine, Denver (Drs Ellison, Mason, Kohler, and Reller); and the Scripps Clinic and Research Foundation, La Jolla, Calif (Dr Curd).

Arch Intern Med. 1986;146(8):1539-1540. doi:10.1001/archinte.1986.00360200097016

• We treated two patients with severe hepatic failure complicated by meningococcemia. Serum complement profiles performed on these patients found low total hemolytic complement assays, normal concentrations of C1q, and low or undetectable concentrations of C3 through C6, C8, C9, and factors B and I. These studies suggest that these patients developed meningococcemia in the setting of acquired complement deficiency from impaired synthesis of multiple complement system proteins.

(Arch Intern Med 1986;146:1539-1540)

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