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August 1986

Chronic Pernio: A Historical Perspective of Cold-Induced Vascular Disease

Author Affiliations

From the Divisions of Rheumatology (Drs Jacob and Weisman) and Endocrinology (Dr Rosenblatt), Department of Medicine, and the Department of Radiology (Dr Bookstein), University of California Medical Center, San Diego. Dr Rosenblatt is now with Smith-Hanna Medical Clinic, San Diego.

Arch Intern Med. 1986;146(8):1589-1592. doi:10.1001/archinte.1986.00360200161026

• Chronic pernio, or cold-induced vascular disease, is an uncommon syndrome with a clinical resemblance to vasculitis or peripheral cholesterol embolization. We studied a case of chronic pernio in which the angiogram revealed extensive vascular changes indistinguishable from vasculitis; pathologic studies of previously reported cases have revealed a primary vasculopathy. The pathophysiology of chronic pernio may be cold-induced vessel damage leading to a secondary dermopathy. Our patient's condition improved once the correct diagnosis was established and appropriate therapy was instituted.

(Arch Intern Med 1986;146:1589-1592)

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