• Chronic pernio, or cold-induced vascular disease, is an uncommon syndrome with a clinical resemblance to vasculitis or peripheral cholesterol embolization. We studied a case of chronic pernio in which the angiogram revealed extensive vascular changes indistinguishable from vasculitis; pathologic studies of previously reported cases have revealed a primary vasculopathy. The pathophysiology of chronic pernio may be cold-induced vessel damage leading to a secondary dermopathy. Our patient's condition improved once the correct diagnosis was established and appropriate therapy was instituted.
(Arch Intern Med 1986;146:1589-1592)
Jacob JR, Weisman MH, Rosenblatt SI, Bookstein JJ. Chronic Pernio: A Historical Perspective of Cold-Induced Vascular Disease. Arch Intern Med. 1986;146(8):1589–1592. doi:10.1001/archinte.1986.00360200161026
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