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August 1986

Multiple Pulmonary Neurofibromas With Hypoxemia: Occurrence due to Pulmonary Arteriovenous Shunts Within the Tumors

Author Affiliations

From the Pulmonary/Allergy (Dr O'Donohue) and Cardiology (Dr Mohiuddin) Divisions, Department of Medicine; the Division of Surgical Pathology (Dr Edland), Department of Pathology; and the Thoracic and Cardiovascular Surgery Section (Dr Schultz), Department of Surgery, Creighton University School of Medicine, Omaha.

Arch Intern Med. 1986;146(8):1618-1619. doi:10.1001/archinte.1986.00360200198032

• A 62-year-old woman with multiple neurofibromas of the lung was found to have severe hypoxemia due to right-to-left shunting within the tumors. Pulmonary angiograms demonstrated that the major area of shunting was in a large tumor mass in the right lower lobe. Pathologically the neurofibromas were vascular with hyperplastic small arteries and arterioles and large dilated veins. Multiple pulmonary neurofibromas are rare; and, to our knowledge, never previously reported in association with pulmonary arteriovenous shunting.

(Arch Intern Med 1986;146:1618-1619)