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September 1986

Chronic Syndrome of Inappropriate Antidiuretic Hormone Secretion and Hypertension in a Patient With Olfactory Neuroblastoma: Evidence of Ectopic Production of Arginine Vasopressin by the Tumor

Author Affiliations

From the Departments of Medicine (Drs Osterman, Calhoun, Cullum, and Stewart) and Surgery (Drs Dunham and Clark), University of South Carolina School of Medicine, Richland Memorial Hospital, and W. J. B. Dorn Veterans Hospital, Columbia; Section of Surgical Pathology, Mayo Clinic and Mayo Foundation, Rochester, Minn (Dr Scheithauer); Department of Neurology (Dr Zimmerman) and Division of Neuropathology (Drs Defendini and Zang), College of Physicians and Surgeons, Columbia University, New York; and Department of Medicine, University of Pittsburgh School of Medicine (Dr Robinson).

Arch Intern Med. 1986;146(9):1731-1735. doi:10.1001/archinte.1986.00360210105016

• A 28-year-old man with the chronic syndrome of inappropriate antidiuretic hormone secretion and hypertension was found to have an olfactory neuroblastoma. We demonstrated evidence of elevated circulating arginine vasopressin levels, significantly elevated arginine vasopressin and vasopressin neurophysin levels in the tumor extract, and immunohistochemical staining for arginine vasopressin and vasopressin neurophysin in the tumor cells. The patient's clinical syndrome, including hypertension, resolved following subtotal removal of the tumor and radiation therapy. This study identified olfactory neuroblastoma as a definite cause of ectopic arginine vasopressin secretion causing the syndrome of inappropriate antidiuretic hormone secretion.

(Arch Intern Med 1986;146:1731-1735)

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