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September 1986

Cholestatic Hepatic Injury Related to Warfarin Exposure

Author Affiliations

From the Divisions of Gastroenterology, University of Louisville, Ky (Dr Adler), and Georgetown University (Dr Benjamin) and Veterans Administration Medical Center (Dr Zimmerman), Washington, DC.

Arch Intern Med. 1986;146(9):1837-1839. doi:10.1001/archinte.1986.00360210235037

• Despite the widespread use of oral anticoagulants derived from 4-hydroxycoumarin, there have been only a small number of well-defined cases of hepatotoxicity. We report a welldefined case of cholestasis following exposure to warfarin sodium (Coumadin). Inadvertent rechallenge reproduced the syndrome. Cholestasis may occur in response to exposure to derivations of 4-hydroxycoumarin.

(Arch Intern Med 1986;146:1837-1839)

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