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October 1986

Calcitriol Levels in Hypercalcemic Patients With Adult T-Cell Lymphoma

Author Affiliations

From the Department of Medicine, University of North Carolina, Chapel Hill (Drs Dodd and Gray and Ms Williams); National Cancer Institute, Navy Medical Oncology Branch, Bethesda, Md (Dr Winkler); and the Department of Medicine, University of Colorado, Denver (Dr Bunn).

Arch Intern Med. 1986;146(10):1971-1972. doi:10.1001/archinte.1986.00360220125022

• Hypercalcemia is a frequent complication in patients with adult T-cell lymphoma. We measured serum calcitriol (1,25-dihydroxyvitamin D3) levels in five hypercalcemic patients with adult T-cell lymphoma and compared the values with those of five patients with mycosis fungoides, a T-cell neoplasm not associated with hypercalcemia. All five patients with adult T-cell lymphoma had calcitriol levels in or below the normal range. These data show that elevated calcitriol levels are not uniformly elevated in this disorder and may not be the usual cause of hypercalcemia in this subgroup of patients with lymphoma.

(Arch Intern Med 1986;146:1971-1972)