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October 1986

Indapamide: Effects on Apoprotein, Lipoprotein, and Glucoregulation in Ambulatory Diabetic Patients

Author Affiliations

From the Division of Endocrinology and Metabolism, Department of Medicine, Ohio State University Hospital, Columbus.

Arch Intern Med. 1986;146(10):1973-1977. doi:10.1001/archinte.1986.00360220131023

• We evaluated the long-term effects of indapamide, a nonthiazide diuretic, on blood pressure, glucoregulation, free insulin and C-peptide levels, and lipoprotein and apoprotein metabolism in 13 hypertensive diabetic patients for 24 weeks. Indapamide significantly reduced both systolic and diastolic blood pressure by 15% and 17%, respectively. Both mean fasting serum glucose and integrated glucose responses after oral glucose load (75 g) were significantly higher during indapamide therapy than at week 0. The mean fasting and stimulated C-peptide responses were significantly increased despite worsening glucose control. At the end of 24 weeks, mean glycosylated hemoglobin level had increased significantly. Indapamide caused a slight but insignificant rise in the total triglyceride, cholesterol, and low-density lipoprotein cholesterol levels, while the high-density lipoprotein cholesterol level decreased. In addition, the apoprotein A-1 concentrations remained unchanged while the apoprotein B-100 level decreased. Apart from hypokalemia (<3.5 mEq/L [<3.5 mmol/L]) in three patients that required oral potassium supplementation, biochemical changes were of no clinical consequence.

(Arch Intern Med 1986;146:1973-1977)

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