• We treated three unrelated patients with hemophilia A and congenital pulmonary valve stenosis. In two patients, the occurrence of the cardiac malformation was sporadic and in one familial. The coexistence of hemophilia A and pulmonary valve stenosis might suggest a genetic linkage for both disorders. Review of the literature supports the hypothesis that the inheritance of pulmonary valve stenosis is dominant and X-linked.
(Arch Intern Med 1986;146:2233-2234)
Ackerman Z, Koren G, Gotsman M, Eldor A. Pulmonary Valve Stenosis and Hemophilia A: Report of Three Cases and Discussion of a Possible Genetic Linkage. Arch Intern Med. 1986;146(11):2233–2234. doi:10.1001/archinte.1986.00360230173024
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