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Article
November 1986

Pulmonary Valve Stenosis and Hemophilia A: Report of Three Cases and Discussion of a Possible Genetic Linkage

Author Affiliations

From the Departments of Internal Medicine A (Dr Ackerman), Cardiology (Drs Koren and Gotsman), and Hematology (Dr Eldor), Hadassah University Hospital; and the Hebrew University Medical School (Drs Ackerman, Koren, Gotsman, and Eldor), Jerusalem.

Arch Intern Med. 1986;146(11):2233-2234. doi:10.1001/archinte.1986.00360230173024
Abstract

• We treated three unrelated patients with hemophilia A and congenital pulmonary valve stenosis. In two patients, the occurrence of the cardiac malformation was sporadic and in one familial. The coexistence of hemophilia A and pulmonary valve stenosis might suggest a genetic linkage for both disorders. Review of the literature supports the hypothesis that the inheritance of pulmonary valve stenosis is dominant and X-linked.

(Arch Intern Med 1986;146:2233-2234)

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