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December 1986

Lysis-Centrifugation Blood Culture Technique: Clinical Impact in Staphylococcus aureus Bacteremia

Author Affiliations

From the Sections of Clinical Microbiology and Infectious Diseases, Mayo Clinic and Mayo Foundation, Rochester, Minn. Dr Washington is now with the Cleveland Clinic Foundation.

Arch Intern Med. 1986;146(12):2341-2343. doi:10.1001/archinte.1986.00360240055010

• To determine the clinical impact of enhanced detection of Staphylococcus aureus by a lysis-centrifugation (LC) blood culture system, consecutive cases of S aureus bacteremia during a seven-month period were reviewed. Of 77 clinically significant cases, the LC system detected 70 cases (91%) while a conventional broth system detected 67 cases (87%). Of 60 cases detected by both systems, the LC system was positive earlier than the broth system by one or more days in 34 cases (57%) and later in none. It also detected more (12 vs four of 13) patients with persistent bacteremia who were receiving antimicrobial treatment. Forty-three patients (56%) did not receive appropriate antimicrobial therapy until cultures were reported positive. Enhanced detection of S aureus bacteremia is a clinically important advantage of the LC blood culture technique.

(Arch Intern Med 1986;146:2341-2343)

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